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Article

Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells.

The Journal of investigative dermatology - 1 Feb 2000

Ma Y, Carter E, Wang X, Shu C, McMahon G, Longley B J

Abstract excerpt

Mastocytosis is a neoplastic disease caused at least in part by somatic mutations of the c-KIT proto-oncogene resulting in constitutive activation of its protein product, KIT, the receptor tyrosine kinase for stem cell factor. KIT stimulates mast cell proliferation and prevents apoptosis of neopl...

Read the complete abstract on PubMed

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Share to Proto-Oncogene Proteins c-kit
Share to Gene Expression Regulation
Share to KIT gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mast Cells

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Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10652004
DOI: 10.1046/j.1523-1747.2000.00888.x

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10652004-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells.PMID 10652004Read ↗

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Nintedanib Targets KIT D816V Neoplastic Cells Derived from Induced Pluripotent Stem cells of Systemic MastocytosisSemantic proximity Read ↗

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Tyrosine Kinase Inhibitors in the Treatment of Eosinophilic Neoplasms and Systemic Mastocytosis.Semantic proximity Read ↗

Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.Semantic proximity Read ↗

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On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts.Semantic proximity Read ↗

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