Article
Role of antioxidants in the survival of normal and vitiliginous avian melanocytes.
Cellular and molecular biology (Noisy-le-Grand, France) - 1 Nov 1999
Bowers R R, Nguyen B, Buckner S, Gonzalez Y, Ruiz F
Abstract excerpt
Mutant feather melanocytes from Barred Plymouth Rock (BPR) and White Leghorn (WL) chickens are currently being used as avian models of vitiligo. Feather melanocytes in BPR and WL chickens die prematurely in vivo due to low (50-66%) antioxidant glutathione and superoxide dismutase levels when compared to the wild type Jungle Fowl (JF) melanocytes. Excess superoxide anions, generated by xanthine:xanthine oxidase...
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