Article
Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile: a pilot study.
Mutation research - 17 Dec 1999
Harrington-Brock K, Cabrera M, Collard D D, Doerr C L, McConnell R, Moore M M, Sandoval H, Fuscoe J C
Abstract excerpt
A pilot biomarker study was conducted to investigate the feasibility of using the hypoxanthine guanine phosphoribosyltransferase (HPRT) gene in peripheral blood lymphocytes as a biomarker for detecting genetic effects of arsenic exposure. Blood and urine samples were obtained from workers highly exposed to arsenic in a copper roasting plant in Antofagasta, Chile. Individuals were classified according to their job...
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