Article
B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion.
Cancer immunology, immunotherapy : CII - 1 Jan 2000
Barbera-Guillem E, Nelson M B, Barr B, Nyhus J K, May K F, Feng L, Sampsel J W
Abstract excerpt
Accumulating data are showing that the humoral immune response against tumors could favor tumor progression. However, no B lymphocyte pathology has been reported in cancer. Using anti-IgM Ab we nonspecifically depleted B cells in tumor-bearing mice, a treatment that resulted in significant reduction of tumor burden. We analyzed the B lymphocyte phenotype of abdominal lymph nodes and peripheral blood from advanced...
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