Article
An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine.
Journal of virology - 1 Feb 2000
Lewis T, Zsak L, Burrage T G, Lu Z, Kutish G F, Neilan J G, Rock D L
Abstract excerpt
The African swine fever virus (ASFV) genome contains a gene, 9GL, with similarity to yeast ERV1 and ALR genes. ERV1 has been shown to function in oxidative phosphorylation and in cell growth, while ALR has hepatotrophic activity. 9GL encodes a protein of 119 amino acids and was highly conserved at both nucleotide and amino acid levels among all ASFV field isolates examined. Monospecific rabbit polyclonal antibody...
Topics
- African Swine Fever
- African Swine Fever Virus
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Conserved Sequence
- DNA-Binding Proteins
- Fungal Proteins
- Gene Deletion
- Immunization
- Macrophages
- Mitochondrial Proteins
- Molecular Sequence Data