Article
Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer.
Journal of the National Cancer Institute - 5 Jan 2000
Shriver S P, Bourdeau H A, Gubish C T, Tirpak D L, Davis A L, Luketich J D, Siegfried J M
Abstract excerpt
BACKGROUND: Activation of gastrin-releasing peptide receptor (GRPR) in human airways has been associated with a proliferative response of bronchial cells to gastrin-releasing peptide and with long-term tobacco use. The GRPR gene is located on the X chromosome and escapes X-chromosome inactivation, which occurs in females. Increasing evidence demonstrates that women are more susceptible than men to tobacco...
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