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Article

Prediction of nonsynonymous single nucleotide polymorphisms in human disease-associated genes.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 1999

Sunyaev S, Hanke J, Aydin A, Wirkner U, Zastrow I, Reich J, Bork P

Abstract excerpt

Analysis of human genetic variation can shed light on the problem of the genetic basis of complex disorders. Nonsynonymous single nucleotide polymorphisms (SNPs), which affect the amino acid sequence of proteins, are believed to be the most frequent type of variation associated with the respective disease phenotype. Complete enumeration of nonsynonymous SNPs in the candidate genes will enable further association...

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PMID: 10619435
DOI: 10.1007/s001099900059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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