Article
Genome bioinformatic analysis of nonsynonymous SNPs.
BMC bioinformatics - 20 Aug 2007
Burke David F, Worth Catherine L, Priego Eva-Maria, Cheng Tammy, Smink Luc J, Todd John A, Blundell Tom L
Abstract excerpt
BACKGROUND: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the most common of which is the non-synonymous single nucleotide polymorphism (nsSNP). It would be an advantage if the functional effects of an nsSNP on protein structure and function could be predicted, both for the final identification...
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