Article
Induction of cytotoxic T lymphocyte activity by fusion-active peptide-containing virosomes.
Vaccine - 31 Jan 2000
Arkema A, Huckriede A, Schoen P, Wilschut J, Daemen T
Abstract excerpt
Priming of cytotoxic T lymphocyte (CTL) activity with exogenous antigen requires introduction of the antigen into the MHC class I presentation pathway of antigen-presenting cells. In the present study, we used fusogenic reconstituted envelopes (virosomes), derived from influenza virus, as a carrier system for delivery of a synthetic soluble peptide corresponding to a major murine CTL epitope of the influenza...
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