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Article

Simulated data for a complex genetic trait (problem 2 for GAW11): how the model was developed, and why.

Genetic epidemiology - 1 Jan 1999

Greenberg D A, MacCluer J W, Spence M A, Falk C T, Hodge S E

Abstract excerpt

This paper describes a simulated data set created as Problem 2 for GAW11. The generating model for Problem 2 involved two different genetic diseases, or "types," in three separate populations. The two-locus (2L) type results from the epistatic interaction of two genetic loci, and the three-allele type, from a single locus with two disease-causing alleles and one normal allele. Each type has two phenotypic forms:...

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PMID: 10597475
DOI: 10.1002/gepi.1370170773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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