Article
The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis.
Microbiology (Reading, England) - 1 Nov 1999
Jennings Michael P, Srikhanta Yogitha N, Moxon E Richard, Kramer Marco, Poolman Jan T, Kuipers Betsy, van der Ley Peter
Abstract excerpt
Neisseria meningitidis strains express a diverse range of lipopolysaccharide (LPS) structures that have been classified into 12 immunotypes. A feature of meningococcal LPS is the reversible, high-frequency switching of expression (phase variation) of terminal LPS structures. A number of studies are strongly suggestive of a key role for these terminal structures, and their phase-variable expression, in...
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