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[A study on mutation of exon 5 of presenilin-1 in Alzheimer's disease].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 1999

Ma Q, Qian C, Liu Z, Lu X, Lin H

Abstract excerpt

OBJECTIVE: To explore the role of the mutation of presenilin-1 in pathogenesis of sporadic Alzheimer's disease. METHODS: The exon 5 of presenilin-1 was analysed by using polymerase chain reaction- single strand conformation polymorphism (PCR-SSCP) and ABI 310 genetic analyzer technique in 68 patients with Alzheimer's disease and 65 normal controls. RESULTS: A mobility shift of SSCP in exon 5 of presenilin-1 was...

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PMID: 10581340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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