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Article

[Mutation site of presenilin-1 gene in familial Alzheimer's disease].

Zhonghua yi xue za zhi - 25 Nov 2002

Xu Erhe, Jia Jianping, Sun Wenjun

Abstract excerpt

OBJECTIVE: To explore the effect of mutation of presenilin-1 (PS-1) gene on the pathogenesis of familial Alzheimer disease (FAD). METHODS: Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP), denaturing high performance liquid chromatography (DHPLC), and DNA sequencing were used to detect the exons 4 and 5 of PS-1 gene of a 130-member family and a 50-member control group. RESULT: PCR-SSCP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 12609057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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