Article
The effect of acrylonitrile on gap junctional intercellular communication in rat astrocytes.
Cell biology and toxicology - 1 Jun 1999
Kamendulis L M, Jiang J, Zhang H, deFeijter-Rupp H, Trosko J E, Klaunig J E
Abstract excerpt
Rats chronically exposed to acrylonitrile (ACN) have shown a dose-dependent increase in the incidence of astrocytomas in the brain. The mechanism(s) by which ACN induces cancer in rodents has not been established. ACN does not appear to be directly genotoxic in the brain and thus a nongenotoxic mode of action has been proposed. Inhibition of gap junctional intercellular communication (GJIC) has been shown to be a...
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