Article
Kinetic and phenotypic changes in murine lymphocytes infected with murine gammaherpesvirus-68 in vitro.
The Journal of general virology - 1 Oct 1999
Dutia Bernadette M, Stewart James P, Clayton Robert A E, Dyson Heather, Nash Anthony A
Abstract excerpt
Primary infection with murine gammaherpesvirus-68 (MHV-68), as with other members of the gammaherpesvirus subfamily, is characterized by a lymphoproliferative phase. MHV-68 causes acute splenomegaly and an infectious mononucleosis-like syndrome in which there is expansion of the CD8+ T cell subset. In long-term infections, MHV-68 is associated with lymphoma development. In order to elucidate the mechanisms...
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