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Article

Fertility of Y(TIR).B6 sex-reversal females with XX orthotopic ovarian transplants.

Biology of reproduction - 1 Dec 1999

Marmolejo-Valencia A, Nishioka Y, Moreno-Mendoza N, Merchant-Larios H

Abstract excerpt

When the Y chromosome of Mus musculus domesticus (Y(TIR)) was introduced onto the C57BL/6J (B6) mouse background, testis development was impaired and half of the XY progeny (Y(TIR).B6) developed a female phenotype. Y(TIR).B6 fetal ovaries showed massive death of medullary oocytes and, after birth, produced abnormal levels of steroid hormones, exhibited irregular estrous cycles, and failed to become fertile. In...

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PMID: 10569985
DOI: 10.1095/biolreprod61.6.1426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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