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Article

Coamplification of prostate stem cell antigen (PSCA) andMYC in locally advanced prostate cancer

1 Jan 2000

Abstract excerpt

Gain of sequences on chromosome arm 8q is a common feature of prostate cancer that may correlate with metastatic and androgen-independent progression. The target gene(s) for this gain is not known, although MYC is amplified in a subset of advanced tumors and is one potential candidate. Prostate stem cell antigen (PSCA) is a prostate-specific cell surface protein that maps to chromosome region 8q24.2 and is...

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PMID: 10564591
DOI: 10.1002/(sici)1098-2264(200001)27:1<95::aid-gcc12>3.0.co;2-3

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