Article
Amplification and overexpression of prosaposin in prostate cancer.
Genes, chromosomes & cancer - 1 Dec 2005
Koochekpour Shahriar, Zhuang Yu-Jun, Beroukhim Rameen, Hsieh Chia-Ling, Hofer Matthias D, Zhau Haiyen E, Hiraiwa Masao, Pattan Daniel Y, Ware Joy L, Luftig Ronald B, Sandhoff Konrad, Sawyers Charles L, Pienta Kenneth J, Rubin Mark A, Vessella Robert L, Sellers William R, Sartor Oliver
Abstract excerpt
We identified prosaposin (PSAP) as a secreted protein expressed in androgen-independent (AI) prostate cancer cells by cloning/sequencing, after probing a PC-3 cDNA library expressed in the lambdaTriplEx phagemid expression vector with a polyclonal rabbit antibody generated against pooled human seminal plasma. PSAP is a neurotrophic molecule; its deficiency or inactivation has proved to be lethal in man and mice,...
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