Article
Periodontal attachment loss in HIV-infected patients is associated with the major histocompatibility complex 8.1 haplotype (HLA-A1,B8,DR3).
Tissue antigens - 1 Oct 1999
Price P, Calder D M, Witt C S, Allcock R J, Christiansen F T, Davies G R, Cameron P U, Rogers M, Baluchova K, Moore C B, French M A
Abstract excerpt
Periodontal attachment loss is mediated by overproduction of tumour necrosis factor (TNF) and interleukin (IL)-1, and appears to have a genetic component. The 8.1 major histocompatibility complex (MHC) ancestral haplotype (HLA-A1,B8,TNFA-308(2),DR3) is associated with elevated TNF production and predisposes carriers to several autoimmune/immunopathological disorders, including rapid progression of HIV disease,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.