Keratinocytes from patients with lupus erythematosus show enhanced cytotoxicity to ultraviolet radiation and to antibody-mediated cytotoxicity

Abstract excerpt

Keratinocyte cytotoxicity is an important component of the immunopathology of photosensitive lupus erythematosus, and antibody-dependent cell-mediated cytotoxicity (ADCC) has been shown to be an important mechanism by which autoantibodies, especially those specific for SS-A/Ro, can induce keratinocyte damage in models of photosensitive lupus. We provide further evidence that keratinocytes from patients with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Psoriasis: Treatment and Pathogenesis
• Share to Skin Protection and Aging
• Share to Systemic Lupus Erythematosus Research