Article
Chromosomal instability of fanconi anemia cells is not the consequence of a defective repair activity of the ribosomal protein S3.
Biochemical and biophysical research communications - 22 Oct 1999
Ramirez M H, Ruppitsch W, Hirsch-Kauffmann M, Schweiger M
Abstract excerpt
Fanconi anemia (FA) is an autosomal recessive chromosomal breakage disorder characterized by developmental defects, hypersensitivity toward oxygen and DNA crosslinking agents, and susceptibility to cancer. An increased level of reactive oxygen intermediates and an increased level of 8-oxoguanine in FA cells point to a defective oxygen metabolism. Recent investigations showed that FA cells from several...
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