Article
Productive infection of double-negative T cells with HIV in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999
Marodon G, Warren D, Filomio M C, Posnett D N
Abstract excerpt
HIV induces CD4 down-regulation from the surface of infected cells by several independent mechanisms, suggesting an important biological role for this phenomenon. In vitro CD4 down-regulation generates T cells with a double-negative (DN) CD4(-)CD8(-) T cell receptor-alphabeta(+) phenotype. However, evidence that this down-regulation occurs in vivo in HIV-infected subjects is lacking, and viral load or viral...
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