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Article

Three-dimensional spheroid cultures of human prostate cancer cell lines.

The Prostate - 1 Nov 1999

Hedlund T E, Duke R C, Miller G J

Abstract excerpt

BACKGROUND: Many of the available human prostate cancer (PC) cell lines have lost androgen sensitivity and no longer secrete prostate-specific proteins after serial culturing in cell monolayers. Three-dimensional spheroid cultures have been found to better mimic the in vivo phenotypes of several nonprostatic cell lines. METHODS: We analyzed seven PC cell lines to determine if spheroid culturing results in greater...

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Identifiers

PMID: 10517873
DOI: 10.1002/(sici)1097-0045(19991101)41:3<154::aid-pros2>3.0.co;2-m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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