Appearance and properties of L-sorbose-utilizing mutants of Candida albicans obtained on a selective plate.

doi:10.1093/genetics/153.2.653

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Article

Appearance and properties of L-sorbose-utilizing mutants of Candida albicans obtained on a selective plate.

Genetics - 1 Oct 1999

Janbon G, Sherman F, Rustchenko E

Abstract excerpt

This is the first report that adaptive mutagenesis can arise by chromosomal nondisjunction, a phenomenon previously associated exclusively with DNA alterations. We previously uncovered a novel regulatory mechanism in Candida albicans in which the assimilation of an alternative sugar, l-sorbose, was determined by copy number of chromosome 5, such that monosomic strains utilized l-sorbose, whereas disomic strains...

Topics

Candida albicans
Chromosome Mapping
Chromosomes, Fungal
Culture Media
Electrophoresis, Gel, Pulsed-Field
Kinetics
Mutagenesis
Phenotype
Sorbose
Time Factors

Source

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Identifiers

PMID: 10511546
DOI: 10.1093/genetics/153.2.653
PMCID: PMC1460764

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