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Article

Monogenic disorders of obesity and body fat distribution

1 Oct 1999

Abstract excerpt

Recently, great progress has been made towards understanding the molecular basis of body fat regulation. Identification of mutations in several genes in spontaneous monogenic animal models of obesity and development of transgenic models have indicated the physiological roles of many genes in the regulation of body fat distribution. In humans, mutations in leptin, leptin receptor, prohormone convertase 1 (PC1),...

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PMID: 10508193
DOI: 10.1016/s0022-2275(20)34890-2

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