Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A yeast model for classical juvenile Batten disease (CLN3).

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society - 1 Jan 2001

Barwell K J, Broom M F

Abstract excerpt

The gene involved in the classical juvenile form of Batten disease, CLN3 has been identified as being highly homologous to the Saccharomyces cerevisiae YHC3 gene. To provide a simple model for the biochemical events underlying this disease, several disruptions have been made in YHC3 in three different S. cerevisiae strains. No obvious growth differences were observed, and neither was the previously reported...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclins
Share to Fungal Proteins
Share to CLN3 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Neuronal Ceroid-Lipofuscinoses

Share to Phenotype

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 11588983
DOI: 10.1053/ejpn.2000.044

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A yeast model for classical juvenile Batten disease (CLN3).PMID 11588983Read ↗

Investigation of Batten disease with the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathwaysSemantic proximity Read ↗

Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype.Semantic proximity Read ↗

The Batten disease gene CLN3 is required for the response to oxidative stress.Semantic proximity Read ↗

Spectrum of mutations in the Batten disease gene, CLN3.Semantic proximity Read ↗

Batten disease: evaluation of CLN3 mutations on protein localization and functionSemantic proximity Read ↗

Novel CLN3 mutation predicted to cause complete loss of protein function does not modify the classical JNCL phenotype.Semantic proximity Read ↗

The fission yeast model for the lysosomal storage disorder Batten disease predicts disease severity caused by mutations in CLN3.Semantic proximity Read ↗

Absence of Btn1p in the yeast model for juvenile Batten disease may cause arginine to become toxic to yeast cells.Semantic proximity Read ↗

Interaction between Sdo1p and Btn1p in the Saccharomyces cerevisiae model for Batten disease.Semantic proximity Read ↗

A model for Batten disease protein CLN3: functional implications from homology and mutations.Semantic proximity Read ↗

Nitric oxide signaling is disrupted in the yeast model for Batten disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.