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Article

Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1).

Development (Cambridge, England) - 1 Oct 1999

Duan D, Yue Y, Zhou W, Labed B, Ritchie T C, Grosschedl R, Engelhardt J F

Abstract excerpt

Previous studies have demonstrated that transcription of the lymphoid enhancer binding factor 1 (Lef1) gene is upregulated in submucosal gland progenitor cells just prior to gland bud formation in the developing ferret trachea. In the current report, several animal models were utilized to functionally investigate the role of LEF1 in initiating and supporting gland development in the airway. Studies on...

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Identifiers

PMID: 10498680
DOI: 10.1242/dev.126.20.4441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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