Article
Detection of a new variant of the mitochondrial glycerol-3-phosphate dehydrogenase gene in Spanish type 2 DM patients.
Biochemical and biophysical research communications - 24 Sept 1999
Gudayol M, Vidal-Taboada J M, Usac E F, Costa A, Cristòbal P, dell'Anna C, Oliva R, Gomis R
Abstract excerpt
To evaluate if potential defects in the FAD-binding domain of the mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) gene could contribute to susceptibility to type 2 diabetes mellitus, we have screened 151 type 2 DM patients for mutations using PCR single-strand conformational polymorphism. Both a single substitution (T to A) at position 18 and a 6-base-pair deletion (TTTTAA) at position 26 of intron 3...
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