Article
A murine model of myocardial microvascular thrombosis.
The Journal of clinical investigation - 1 Sept 1999
Christie P D, Edelberg J M, Picard M H, Foulkes A S, Mamuya W, Weiler-Guettler H, Rubin R H, Gilbert P, Rosenberg R D
Abstract excerpt
Disorders of hemostasis lead to vascular pathology. Endothelium-derived gene products play a critical role in the formation and degradation of fibrin. We sought to characterize the importance of these locally produced factors in the formation of fibrin in the cardiac macrovasculature and microvasculature. This study used mice with modifications of the thrombomodulin (TM) gene, the tissue-type plasminogen...
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