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Article

Reduced human growth hormone (hGH) bioactivity without a defect of the GH-1 gene in three patients with rhGH responsive growth failure.

Clinical endocrinology - 1 Jul 1999

Binder G, Benz M R, Elmlinger M, Pflaum C D, Strasburger C J, Ranke M B

Abstract excerpt

BACKGROUND: A GH deficiency-like phenotype with normal or high hGH secretion, pathologically low IGF-I serum levels, and catch-up growth under treatment with recombinant hGH is suggestive of the presence of biologically inactive hGH syndrome, whose presumably heterogenous molecular basis is substantially unknown. DESIGN: Serum samples from patients who fulfilled the above criteria and from controls with...

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PMID: 10468970
DOI: 10.1046/j.1365-2265.1999.00744.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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