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Article

Severe short stature and endogenous growth hormone resistance in twin brothers without growth hormone gene mutations.

Endocrine - 1 Aug 2003

Walvoord Emily C, Sloop Kyle W, Dwyer Conor J, Rhodes Simon J, Pescovitz Ora H

Abstract excerpt

Growth failure in children with high growth hormone (GH) levels, low insulin-like growth factor 1 (IGF-1) levels, and accelerated linear growth in response to exogenous GH is presumed to result from biologically inactive GH. A molecular diagnosis has only been made in two such patients. We analyzed the presentations and the GH-1 genes of twin Egyptian brothers with this phenotype. At 8 yr of age, the boys'...

Topics

Child
Diseases in Twins
Egypt
Growth Disorders
Human Growth Hormone
Humans
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Male
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Sequence Analysis, DNA

Severity of Illness Index

Source

Identifiers

PMID: 14515015
DOI: 10.1385/ENDO:21:3:289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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