Article
Up-regulation of Lewis enzyme (Fuc-TIII) and plasma-type alpha1,3fucosyltransferase (Fuc-TVI) expression determines the augmented expression of sialyl Lewis x antigen in non-small cell lung cancer.
International journal of cancer - 24 Sept 1999
Togayachi A, Kudo T, Ikehara Y, Iwasaki H, Nishihara S, Andoh T, Higashiyama M, Kodama K, Nakamori S, Narimatsu H
Abstract excerpt
Sialyl Lewis a and x antigens are well-known tumor-associated antigens expressed in many cancer tissues. The expression of the genes encoding 5 alpha1,3fucosyltransferases, which are able to synthesize the sialyl Lewis antigens, was examined in normal and cancerous lung tissues of patients with non-small cell lung carcinoma. In all 20 cases examined, the transcripts only for the Lewis gene, encoding the Lewis...
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