Article
The Candida albicans INT1 gene facilitates cecal colonization in endotoxin-treated mice.
Shock (Augusta, Ga.) - 1 Jun 2000
Bendel C M, Kinneberg K M, Jechorek R P, Erlandsen S L, Sahar D E, Wells C L
Abstract excerpt
Increased intestinal colonization with Candida albicans is believed to be a major predisposing factor to systemic candidiasis. Previous evidence has implicated the C. albicans INT1 gene in hyphal development, epithelial adherence, and mouse virulence. The effect of INT1 on mouse cecal colonization was measured using a parent strain (CAF2, INT1/INT1), an int1 deletion homozygote (CAG3, int1/int1), and a...
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