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Article

Methylenetetrahydrofolate reductase thermolabile variant and oral clefts.

American journal of medical genetics - 3 Sept 1999

Mills J L, Kirke P N, Molloy A M, Burke H, Conley M R, Lee Y J, Mayne P D, Weir D G, Scott J M

Abstract excerpt

Folic acid can prevent neural tube defects; in some cases the mechanism is probably a correction of a metabolic defect caused by thermolabile methylenetetrahydrofolate reductase (MTHFR) found in increased frequency in cases. It is less clear whether folic acid can prevent oral clefts, in part bec...

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Source

Identifiers

PMID: 10440833

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10440833-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Methylenetetrahydrofolate reductase thermolabile variant and oral clefts.PMID 10440833Read ↗

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Methylenetetrahydrofolate reductase C677T polymorphism is not associated with the risk of nonsyndromic cleft lip/palate: An updated meta-analysis.Semantic proximity Read ↗

Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.Semantic proximity Read ↗

Association between MTHFR polymorphisms and orofacial clefts risk: a meta-analysis.Semantic proximity Read ↗

Infants' MTHFR polymorphisms and nonsyndromic orofacial clefts susceptibility: a meta-analysis based on 17 case-control studies.Semantic proximity Read ↗

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5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects.Semantic proximity Read ↗

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