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Article

A Mouse Gene Encoding an Oocyte Antigen Associated with Autoimmune Premature Ovarian Failure

1 Aug 1999

Abstract excerpt

Autoimmune premature ovarian failure causes young women to develop menopausal symptoms and infertility. A similar syndrome appears in mice with postthymectomy autoimmune premature ovarian failure. We demonstrate that these mice develop antibodies against a 125-kDa protein located in the oocyte cytoplasm (ooplasm). By screening a mouse ovarian complementary DNA expression library with autoimmune serum, we have...

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Identifiers

PMID: 10433232
DOI: 10.1210/endo.140.8.6911

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