[Susceptibility gene location of simple congenital heart defect by transmission disequilibrium test].

Abstract excerpt

OBJECTIVE: To locate the susceptibility gene of human simple congenital heart defect(CHD) and provide a sound basis for further gene cloning. METHODS: Three short tandem repeats(STRs) in regions of chromosome 7p14-15, 17q21 where exist Hox gene family's A, B clusters which regulate the embryonic heart development were chosen. Genotypes of 112 members in 39 CHD families were analyzed by amplifying the STR...

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