Selecting a contingency table in a population-based association study: allele frequency or positivity?

Abstract excerpt

In population-based association studies, the significance of the association between a candidate gene and a disease is usually examined by a simple chi 2 test. Such studies require a 2 x 2 contingency table made up of either allele frequencies or positivities in affected and control groups. In order to investigate the influence of each 2 x 2 table on the power of the chi 2 test, P values were calculated for two...

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