Article
Comparison of statistical power between 2 * 2 allele frequency and allele positivity tables in case-control studies of complex disease genes.
Annals of human genetics - 1 Mar 2001
Ohashi J, Yamamoto S, Tsuchiya N, Hatta Y, Komata T, Matsushita M, Tokunaga K
Abstract excerpt
In case-control studies of complex disease genes, allele frequencies or allele positivities at candidate loci or markers are compared between cases and controls. Although 2 x 2 contingency tables based on allele frequency and allele positivity are generally used to perform simple statistical tests (e.g. a comparison of two proportions and a chi2 test), little is known about the difference in power between the two...
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