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Article

A defect in cell wall recycling triggers autolysis during the stationary growth phase of Escherichia coli.

The EMBO journal - 2 Aug 1999

Templin M F, Ursinus A, Höltje J V

Abstract excerpt

The first gene of a family of prokaryotic proteases with a specificity for L,D-configured peptide bonds has been identified in Escherichia coli. The gene named ldcA encodes a cytoplasmic L, D-carboxypeptidase, which releases the terminal D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine containing turnover products of the cell wall polymer murein. This reaction turned out to be essential for...

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Identifiers

PMID: 10428950
DOI: 10.1093/emboj/18.15.4108
PMCID: PMC1171488

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Source receipt: pubmed, retrieved 7 Sept 2026.

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