Article
Exclusion of linkage to the HLA region in ninety multiplex sibships with autism.
Journal of autism and developmental disorders - 1 Jun 1999
Rogers T, Kalaydjieva L, Hallmayer J, Petersen P B, Nicholas P, Pingree C, McMahon W M, Spiker D, Lotspeich L, Kraemer H, McCague P, Dimiceli S, Nouri N, Peachy T, Yang J, Hinds D, Risch N, Myers R M
Abstract excerpt
Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the...
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