Article
Ideas in theoretical biology. Origin of cancerous cells from tumours.
Acta biotheoretica - 1 Jan 2000
Niu D K, Chen J K
Abstract excerpt
With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in...
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