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Article

Phenotype divergence and cooperation in isogenic multicellularity and in cancer.

Mathematical medicine and biology : a journal of the IMA - 15 Jun 2024

Ernesto Alvarez Frank, Clairambault Jean

Abstract excerpt

We discuss the mathematical modelling of two of the main mechanisms that pushed forward the emergence of multicellularity: phenotype divergence in cell differentiation and between-cell cooperation. In line with the atavistic theory of cancer, this disease being specific of multicellular animals, we set special emphasis on how both mechanisms appear to be reversed, however not totally impaired, rather hijacked, in...

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Identifiers

PMID: 38970827
DOI: 10.1093/imammb/dqae005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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