Article
Application of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) lipid conjugates as steric barrier molecules in liposomal formulations.
Bioconjugate chemistry - 1 Jan 2000
Ansell S M, Kojic L D, Hankins J S, Sekirov L, Boey A, Lee D K, Bennett A R, Klimuk S K, Harasym T O, Dos Santos N, Semple S C
Abstract excerpt
Lipid conjugates of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) (ATTAn) were synthesized as monodisperse analogues of poly(ethylene glycol) (PEG) derivatives used in liposomal drug delivery systems. The new lipids were shown to be at least equivalent to MePEGA-2000-DSPE in assays designed to evaluate the effectiveness of polymers as steric barrier molecules in liposomes. Liposomes containing 1-5% of...
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