Mutations in Bcl10 are very rare in colorectal cancer.

Abstract excerpt

Bcl10 is a recently identified gene reported to be involved commonly in human malignancy (Willis et al (1999) Cell 96: 1-20). To investigate whether it is frequently mutated in colorectal cancer we have analysed a series of 132 colorectal cancers and eight colorectal cancer cell lines for mutations in Bcl10. One feature of the Bcl10 gene is that it harbours two polyadenine tracts. These repeating elements in...

Topics

• Adaptor Proteins, Signal Transducing
• B-Cell CLL-Lymphoma 10 Protein
• Colorectal Neoplasms
• Humans
• Mutation
• Neoplasm Proteins
• Polymerase Chain Reaction
• Polymorphism, Single-Stranded Conformational
• Tumor Cells, Cultured