Article
Cloning of E6 and E7 genes of human papilloma virus type 18 and transformation potential of E7 gene and its mutants.
Virus genes - 1 Jan 1999
Laassri M, Gul'ko L, Vinokurova S, Kisseljova N, Veiko V, Kisseljov F
Abstract excerpt
E6 and E7 genes of human papilloma virus type 18 have been subcloned from plasmid pC7, carrying an insert of DNA from squamous cell carcinoma of cervix. Both genes in comparison to prototype variant contain one mutation that changes asparagine to leucine. In the case of E6 gene this mutation is mapped in codon 129, in the case of E7 the same change AAC to AAA mapped in codon 92. In addition both genes contain few...
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