Article
Germline brca2 sequence variants in patients with ocular melanoma.
International journal of cancer - 30 Jul 1999
Sinilnikova O M, Egan K M, Quinn J L, Boutrand L, Lenoir G M, Stoppa-Lyonnet D, Desjardins L, Levy C, Goldgar D, Gragoudas E S
Abstract excerpt
On the basis, chiefly, of anecdotal reports of cases of ocular melanoma (OM) occurring in families with inherited susceptibility to breast cancer due to brca2 germline mutations, we examined the frequency of brca2 alterations in a series of 62 ocular melanoma cases. These cases were preferentially selected on the basis of reported family history of breast or ovarian cancer, or OM, although the series also...
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