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Article

Clonal T-cell receptor ?-chain gene rearrangement by PCR-based GeneScan analysis in advanced cutaneous T-cell lymphoma: a critical evaluation

1 Jun 1999

Abstract excerpt

Detection of clonal T-cell receptor gamma (TCRgamma)-chain gene rearrangement is a promising approach to distinguish between cutaneous T-cell lymphomas (CTCLs) and reactive T-cell infiltrates. Despite the improved sensitivity by using the polymerase chain reaction (PCR) rather than Southern blot analysis, monoclonality could be demonstrated in only 53-90 per cent of CTCL biopsies in recent studies. In the present...

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PMID: 10398157
DOI: 10.1002/(sici)1096-9896(199906)188:2<146::aid-path334>3.0.co;2-7

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