Article
Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours.
British journal of cancer - 1 Apr 1999
Ghimenti C, Tannergård P, Wahlberg S, Liu T, Giulianotti P G, Mosca F, Fornaciari G, Bevilacqua G, Lindblom A, Caligo M A
Abstract excerpt
Genomic instability has been proposed as a new mechanism of carcinogenesis involved in hereditary non-polyposis colorectal cancer (HNPCC) and in a large number of sporadic cancers like pancreatic and colon tumours. Mutations in human mismatch repair genes have been found in HNPCC patients, but their involvement in sporadic cancer has not been clarified yet. In this study we screened 21 pancreatic and 23...
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