Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.

doi:10.1038/sj.bjc.6690313

Article

Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.

British journal of cancer - 1 Apr 1999

Burt E C, McGown G, Thorncroft M, James L A, Birch J M, Varley J M

Abstract excerpt

We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.

Abstract excerpt

Topics

Related research