Article
The hereditary transmission of the glutathione transferase hGSTT1-1 conjugator phenotype in a large family.
Pharmacogenetics - 1 Apr 1999
Wiebel F A, Dommermuth A, Thier R
Abstract excerpt
The polymorphism of human glutathione transferase hGSTT1-1 is expressed in three phenotypes. Experimentally, individuals can be classified as non-conjugators, low conjugators and 'high' conjugators depending on the enzyme activity in blood towards methylene chloride using a gas chromatographic assay. Non-conjugators do not have a functional hGSTT1 gene; however, little is known about the molecular basis of the...
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